N-linked glycosylation is a complex, co- and post-translational series of events that connects metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans multiple cellular compartments, and early N-linked glycan biosynthesis is a central mediator of protein folding and the unfolded protein response (UPR). In the brain, N-linked glycosylated proteins participate in a myriad of processes, from electrical gradients to neurotransmission. However, it is less clear how perturbations in N-linked glycosylation impact and even potentially drive aspects of neurological disorders. In this review, we discuss our current understanding of the metabolic origins of N-linked glycans in the brain, their role in modulating neuronal function, and how aberrant N-linked glycosylation can drive neurological disorders.

N连接糖基化是一个复杂的、共翻译和翻译后的一系列事件，它在几乎所有细胞中将新陈代谢与信号传导联系起来。N-连接聚糖的代谢组装跨越多个细胞区室，早期的N-连接聚糖生物合成是蛋白质折叠和未折叠蛋白质反应 (UPR) 的中心介质。在大脑中，N-连接糖基化蛋白参与从电梯度到神经传递的无数过程。然而，尚不清楚N连接糖基化的扰动如何影响甚至潜在地驱动神经系统疾病的各个方面。在这篇综述中，我们讨论了我们目前对N代谢起源的理解大脑中的连接聚糖，它们在调节神经元功能中的作用，以及异常的N连接糖基化如何导致神经系统疾病。