Importance Clinical evidence suggests that the time of day of treatment can affect outcomes in many different diseases, but this information is dispersed, imprecise, and heterogeneous. Consequently, practice guidelines and clinical care recommendations seldom specify intervention time.

中文翻译：

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与药物时间效应相关的因素：荟萃分析

重要性临床证据表明，一天中的治疗时间会影响许多不同疾病的结果，但这些信息是分散的、不精确的和异质的。因此，实践指南和临床护理建议很少指定干预时间。