Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: a 6-Year Follow-up Study,Journal of Cardiovascular Translational Research

当前位置： X-MOL 学术 › J. of Cardiovasc. Trans. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: a 6-Year Follow-up Study
Journal of Cardiovascular Translational Research ( IF 2.4 ) Pub Date : 2021-10-28 , DOI: 10.1007/s12265-021-10180-2
Ignatios Ikonomidis _{1,

2} , John Thymis ₁ , Panagiotis Simitsis ₁ , Georgia-Angeliki Koliou ₁ , Spiridon Katsanos ₁ , Charilaos Triantafyllou ₁ , Foteini Kousathana ₃ , George Pavlidis ₁ , Aikaterini Kountouri ₃ , Eftihia Polyzogopoulou ₁ , Konstantinos Katogiannis ₁ , Dimitrios Vlastos ₁ , Gavriella Kostelli ₁ , Helen Triantafyllidi ₁ , John Parissis ₁ , Evangelia Papadavid ₄ , John Lekakis ₁ , Gerasimos Filippatos ₁ , Vaia Lambadiari ₃

Affiliation

We investigated whether disturbance of glycocalyx integrity is related with increased cardiovascular risk. In 600 healthy subjects, we measured perfused boundary region (PBR), a marker of glycocalyx integrity, in sublingual microvessels with diameter ranging 5–25 µm using a dedicated camera (Sideview Darkfield Imaging). Increased PBR indicates reduced glycocalyx thickness. We prospectively monitored the occurrence of cardiovascular events (MACE-death, myocardial infarction, and stroke) during a 6-year follow-up. Fifty-seven MACE were documented. Increased values of PBR5-25 predicted higher risk for MACE in a model including sex, age, hyperlipidemia, diabetes, hypertension, smoking, family history of coronary disease, treatment with ACEi/ARBs, or lipid-lowering agents (hazard ratio (HR), 6.44, p = 0.011; net reclassification improvement (NRI), 28%; C-statistic: 0.761). PBR5-25 was an independent and additive predictor of outcome when added in a model including the European Heart SCORE, diabetes, family history of CAD, and medication (HR, 4.71; NRI: 39.7%, C-statistic from 0.653 to 0.693; p < 0.01).Glycocalyx integrity is an independent and additive predictor to risk factors for MACE at 6-year follow-up in individuals without cardiovascular disease. ClinicalTrials.govIdentifier:NCT04646252.

Graphical abstract

PBR5-25 was an independent and additive predictor of adverse cardiovascular events in a model including the European Heart SCORE, diabetes, family history of coronary disease, and medication (HR: 4.71, NRI: 39.7%, C-statistic from 0.653 to 0.693; p < 0.01, NRI:37.9%).

中文翻译：

受损的内皮糖萼可预测无明显心血管疾病的受试者的不良后果：一项 6 年随访研究

我们研究了糖萼完整性的紊乱是否与心血管风险增加有关。在 600 名健康受试者中，我们使用专用相机（侧视暗场成像）测量了直径范围为 5-25 µm 的舌下微血管中的灌注边界区域 (PBR)，这是糖萼完整性的标志。PBR 增加表明糖萼厚度减少。我们在 6 年随访期间前瞻性监测了心血管事件（MACE 死亡、心肌梗塞和中风）的发生情况。记录了 57 起 MACE。在包括性别、年龄、高脂血症、糖尿病、高血压、吸烟、冠心病家族史、ACEi/ARB 治疗或降脂药物的模型中，PBR5-25 值的增加预示着 MACE 的风险更高（风险比 (HR) ，6.44，p = 0.011；净重分类改进 (NRI)，28%；C 统计量：0.761）。当添加到包括欧洲心脏 SCORE、糖尿病、CAD 家族史和药物的模型中时，PBR5-25 是结果的独立附加预测因子（HR，4.71；NRI：39.7%，C 统计量从 0.653 到 0.693；p < 0.01)。在无心血管疾病的个体中，糖萼完整性是 6 年随访中 MACE 危险因素的独立和附加预测因子。ClinicalTrials.gov 标识符：NCT04646252。