An entry to new classes of nitrogen-containing heterocycles featuring both a cyanamide and an unsaturated 5-, 6- or 7-membered ring is reported. They can be readily obtained by ring-closing metathesis of the corresponding N-alkenyl-cyanamides – new partners for olefin metathesis that can be easily obtained by copper- or palladium-catalyzed alkenylation of cyanamides – using Hoveyda–Grubbs or Grubbs second generation catalysts. In addition to the potential of these novel heterocycles in drug discovery or as building blocks, the presence of the endocyclic double bond was shown to provide a useful access to novel polycyclic heterocycles.

中文翻译：

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N-烯基-氰胺的闭环复分解

报道了一种新类别的含氮杂环，其特征是氰胺和不饱和的 5、6 或 7 元环。它们可以通过相应的N-烯基-氰胺的闭环复分解轻松获得 - 烯烃复分解的新伙伴，可以通过铜或钯催化的氰胺的烯基化轻松获得 - 使用 Hoveyda-Grubbs 或 Grubbs 第二代催化剂。除了这些新型杂环在药物发现中或作为构建块的潜力外，内环双键的存在被证明为获得新型多环杂环提供了有用的途径。