Purpose

To establish the time course of lid wiper epitheliopathy (LWE) in established CL wearers after a single day (6–10 h) of daily disposable contact lens (CL) wear, the following day post-CL removal and 1-week after CL discontinuation.

Methods

Twenty-one symptomatic (CLDEQ-8 score ≥ 12) habitual wearers of MyDay® silicone hydrogel daily disposable were included. LWE staining was assessed prior to CL wear (Visit 1, V1) using semi-automated analysis after instillation of two drops of 1 % lissamine green (10 μL) that were applied to the superior bulbar conjunctiva. LWE measurements were repeated after 6–10 h of continuous CL wear (Visit 2, V2), post-CL removal the following day (Visit 3, V3) and after 1-week CL discontinuation (Visit 4, V4). At each visit, ocular symptoms were evaluated using the SPEED-8 questionnaire and set of 0–100 visual analogue scales (VAS).

Results

LWE showed no significant changes after 6–10 h of continuous CL wear (p = 0.536), post-CL removal the following day (p = 0.677) or following 1-week of CL discontinuation (p = 0.478). Analysis revealed a significant improvement in symptomatology between V1 and V2 (SPEED-8, p < 0.01) and also improvements in the 0–100 VAS scores between V2 and V4 for average daily dryness (p < 0.01), end-of-day dryness (p < 0.01) and frequency of end-of-day dryness (p < 0.05).

Conclusion

The present data suggest that the etiology of LWE is multifactorial and the sole intervention of temporarily discontinuing CL wear does not lead to resolution of these clinical signs.

中文翻译：

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有症状的隐形眼镜佩戴者的眼睑擦拭器上皮病 (LWE) 的自然病程

目的

确定已建立的 CL 佩戴者在每日一次性隐形眼镜 (CL) 佩戴一天（6-10 小时）、摘除 CL 后第二天和停止 CL 后 1 周后眼睑擦拭器上皮病变 (LWE) 的时间进程.

方法

包括 21 名有症状（CLDEQ-8 评分 ≥ 12）的 MyDay® 硅水凝胶日抛习惯佩戴者。在将两滴 1% 丽丝胺绿 (10 μL) 滴入上球结膜后，使用半自动分析在 CL 磨损之前（访问 1，V1）评估 LWE 染色。在连续 CL 磨损 6-10 小时后（访问 2，V2）、第二天去除 CL 后（访问 3、V3）和 CL 中断 1 周后（访问 4、V4）重复 LWE 测量。在每次就诊时，使用 SPEED-8 问卷和一组 0-100 视觉模拟量表 (VAS) 评估眼部症状。

结果

LWE 在 CL 连续磨损 6-10 小时后（p = 0.536）、CL 移除后第二天（p = 0.677）或 CL 停用 1 周后（p = 0.478）没有显示出显着变化。分析显示 V1 和 V2 之间的症状有显着改善（SPEED-8，p < 0.01），并且 V2 和 V4 之间的平均每日干燥（p < 0.01）、一天结束干燥的 0-100 VAS 得分也有所改善(p < 0.01) 和一天结束时干燥的频率 (p < 0.05)。

结论

目前的数据表明，LWE 的病因是多因素的，暂时停止佩戴 CL 的唯一干预措施并不能解决这些临床症状。