Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12–68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, p_FDR = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, p_spin = 0.024), but not BD (r = 0.166, p_spin = 0.205) or MDD (r = −0.274, p_spin = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = −0.690, p_spin = 0.006), BD (rho = −0.672, p_spin = 0.009), and MDD (rho = −0.692, p_spin = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype.

从高危阶段（包括高度分裂型）到早期和慢性精神病，神经解剖学异常已被连续报道。然而，精神分裂症的综合神经解剖图仍有待建立。作者对健康个体的精神分裂症的皮层和皮层下形态测量模式进行了首次大规模荟萃分析，并将这些模式与在主要精神疾病中观察到的神经解剖学异常进行了比较。该样本包括来自全球 ENIGMA 精神分裂症工作组的 29 个队列的 3004 名未接受药物治疗的健康个体（12-68 岁，46.5% 为男性）。使用标准化方法生成具有分裂型评分的皮质和皮质下效应大小图。在精神分裂症 (SZ)、双相情感障碍 (BD) 和重度抑郁症 (MDD) 患者与对照组的比较中，评估了与精神分裂症相关的皮层和皮层下图以及效应大小图之间的模式相似性。较厚的右内侧眶额叶/腹内侧前额叶皮层 (mOFC/vmPFC) 与较高的分裂型评分相关（r  = 0.067，p _FDR  = 0.02）。分裂型的皮质厚度分布与 SZ 的皮质异常呈正相关（r  = 0.285，p _spin  = 0.024），但与 BD（r  = 0.166，p _spin  = 0.205）或 MDD（r  = −0.274，p _spin  = 0.073 ）无关). 分裂型相关皮质下体积模式与 SZ（rho = −0.690， p _spin  = 0.006）、BD（rho = −0.672，p _spin  = 0.009）和 MDD（rho = −0.692，p _spin ）的皮质下异常呈负相关 = 0.004）。一般人群中与精神分裂症相关的脑形态计量学的综合绘图揭示了较高的精神分裂症与较厚的 mOFC/vmPFC 之间的显着关系，在没有抗精神病药物或疾病慢性引起的混杂效应的情况下。精神分裂症和精神分裂症之间的皮层模式相似性产生了对跨扩展精神病表型的维度神经生物学连续性的新见解。