Purpose To investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample. Methods Data from the 1999–2008 cycles of the National Health and Nutrition Examination Survey were used. A self-reported history of cataract surgery was considered a surrogate for the presence of clinically significant cataract surgery. Mortality data were ascertained from National Death Index records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for survival were estimated using Cox proportional hazards regression models. Results A total of 14 918 participants were included in the analysis. During a median follow-up of 10.8 (Interquartile range, IQR, 8.25–13.7) years, 3966 (19.1%) participants died. Participants with self-reported cataract surgery were more likely to die from all causes and specific causes (vascular disease, cancer, accident, Alzheimer’s disease, respiratory disease, renal disease and others) compared with those without (all Ps <0.05). The association between self-reported cataract surgery and all-cause mortality remained significant after multiple adjustments (HR=1.13; 95% CI 1.01 to 1.26). For cause-specific mortality, multivariable Cox models showed that self-reported cataract surgery predicted a 36% higher risk of vascular-related mortality (HR=1.36; 95% CI 1.01 to 1.82). The association with other specific causes of mortality did not reach statistical significance after multiple adjustments. Conclusions This study found significant associations of self-reported cataract surgery with all-cause and vascular mortalities. Our findings provide potential insights into the pathogenic pathways underlying cataract. Data are available upon reasonable request.

中文翻译：

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自我报告的白内障手术和 10 年全因和特定原因死亡率：来自国家健康和营养检查调查的结果

目的 使用大规模人群样本调查自我报告的白内障手术与全因死亡率和特定原因死亡率之间的关联。方法 使用了 1999-2008 年全国健康和营养检查调查周期的数据。自我报告的白内障手术史被认为是有临床意义的白内障手术的替代指标。死亡率数据是根据国家死亡指数记录确定的。使用 Cox 比例风险回归模型估计生存的风险比 (HR) 和 95% 置信区间 (CI)。结果 共有 14 918 名参与者被纳入分析。在 10.8 年（四分位距，IQR，8.25-13.7）年的中位随访期间，3966 名 (19.1%) 参与者死亡。与未接受过白内障手术的参与者相比，接受过白内障手术的参与者更有可能死于所有原因和特定原因（血管疾病、癌症、事故、阿尔茨海默病、呼吸系统疾病、肾脏疾病等）（所有 Ps <0.05）。多次调整后，自我报告的白内障手术与全因死亡率之间的关联仍然显着（HR=1.13；95% CI 1.01 至 1.26）。对于特定原因死亡率，多变量 Cox 模型显示，自我报告的白内障手术预测血管相关死亡率的风险高 36%（HR=1.36；95% CI 1.01 至 1.82）。在多次调整后，与其他特定死亡原因的关联未达到统计学意义。结论 本研究发现自我报告的白内障手术与全因死亡率和血管性死亡率显着相关。我们的研究结果为白内障潜在的致病途径提供了潜在的见解。可根据合理要求提供数据。