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Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2021-10-25 , DOI: 10.1016/j.csbj.2021.10.028 Huiwen Xiao 1, 2 , Yao Fan 3 , Yuan Li 2 , Jiali Dong 2 , Shuqin Zhang 2 , Bin Wang 2 , Jia Liu 1 , Xingzhong Liu 1 , Saijun Fan 2 , Jian Guan 3 , Ming Cui 2
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2021-10-25 , DOI: 10.1016/j.csbj.2021.10.028 Huiwen Xiao 1, 2 , Yao Fan 3 , Yuan Li 2 , Jiali Dong 2 , Shuqin Zhang 2 , Bin Wang 2 , Jia Liu 1 , Xingzhong Liu 1 , Saijun Fan 2 , Jian Guan 3 , Ming Cui 2
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Oral mucositis is a common radiotherapy-induced complication among nasal, oral and laryngeal cancer (NOALC) patients. This complication leads to decreased quality of life and has few treatments. Here, fractionated radiation was performed to mimic radiotherapy for NOALCs in mouse models. Oral microbiota transplantation (OMT) mitigated oral mucositis, as judged by reconstructed epithelium and tongue papillae, fewer infiltrated leukocytes and more proliferative cells in the oral epithelium. The gut microbiota impacted oral mucositis progression, and OMT restructured oral and gut bacteria configurations and reprogrammed the gene expression profile of tongue tissues. silencing of glossal S100 calcium binding protein A9 debilitated the radioprotection of OMT. In light of clinical samples, we identified that patients with different alteration trends of frequency presented different primary lesions and prognoses of NOALC following radiotherapy. Together, our findings provide new insights into the oral-gut microbiota axis and underpin the suggestion that OMT might be harnessed as a novel remedy to fight against oral mucositis in NOALC patients following radiotherapy in preclinical settings. Of note, oral microorganisms, such as , might be employed as biomarkers to predict the prognosis of NOALC with radiotherapy.
中文翻译：
口腔微生物群移植可对抗头颈放疗引起的小鼠口腔粘膜炎
口腔粘膜炎是鼻癌、口腔癌和喉癌（NOALC）患者常见的放疗引起的并发症。这种并发症会导致生活质量下降，并且治疗方法很少。在这里，进行分段放射以模拟小鼠模型中 NOALC 的放射治疗。根据重建的上皮和舌乳头、口腔上皮中浸润白细胞的减少和增殖细胞的增加来判断，口腔微生物群移植（OMT）减轻了口腔粘膜炎。肠道微生物群影响口腔粘膜炎的进展，OMT 重组了口腔和肠道细菌的结构，并重新编程了舌头组织的基因表达谱。舌 S100 钙结合蛋白 A9 的沉默削弱了 OMT 的辐射防护能力。根据临床样本，我们发现不同频率变化趋势的患者在放疗后表现出不同的原发病灶和 NOALC 预后。总之，我们的研究结果为口腔肠道微生物群轴提供了新的见解，并支持了这样的建议：OMT 可以作为一种新疗法来对抗临床前放射治疗后的 NOALC 患者的口腔粘膜炎。值得注意的是，口腔微生物，例如 ，可用作生物标志物来预测放疗后 NOALC 的预后。
更新日期：2021-10-25
中文翻译：
口腔微生物群移植可对抗头颈放疗引起的小鼠口腔粘膜炎
口腔粘膜炎是鼻癌、口腔癌和喉癌（NOALC）患者常见的放疗引起的并发症。这种并发症会导致生活质量下降，并且治疗方法很少。在这里，进行分段放射以模拟小鼠模型中 NOALC 的放射治疗。根据重建的上皮和舌乳头、口腔上皮中浸润白细胞的减少和增殖细胞的增加来判断，口腔微生物群移植（OMT）减轻了口腔粘膜炎。肠道微生物群影响口腔粘膜炎的进展，OMT 重组了口腔和肠道细菌的结构，并重新编程了舌头组织的基因表达谱。舌 S100 钙结合蛋白 A9 的沉默削弱了 OMT 的辐射防护能力。根据临床样本，我们发现不同频率变化趋势的患者在放疗后表现出不同的原发病灶和 NOALC 预后。总之，我们的研究结果为口腔肠道微生物群轴提供了新的见解，并支持了这样的建议：OMT 可以作为一种新疗法来对抗临床前放射治疗后的 NOALC 患者的口腔粘膜炎。值得注意的是，口腔微生物，例如 ，可用作生物标志物来预测放疗后 NOALC 的预后。
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