Sepsis is an overwhelming inflammatory response to microbial infection. Sepsis management remains a clinical challenge. The role of the gut microbiome in sepsis has gained some attention. Recent evidence has demonstrated that gut microbiota regulate host physiological homeostasis mediators, including the immune system, gut barrier function and disease susceptibility pathways. Therefore, maintenance or restoration of microbiota and metabolite composition might be a therapeutic or prophylactic target against critical illness. Fecal microbiota transplantation and supplementation of probiotics are microbiota-based treatment methods that are somewhat limited in terms of evidence-based efficacy. This review focuses on the importance of the crosstalk between the gastrointestinal ecosystem and sepsis to highlight novel microbiota-targeted therapies to improve the outcomes of sepsis treatment.

中文翻译：

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肠道微生物群与脓毒症之间的串扰


脓毒症是对微生物感染的压倒性炎症反应。脓毒症管理仍然是一个临床挑战。肠道微生物组在脓毒症中的作用引起了一些关注。最近的证据表明，肠道微生物群调节宿主生理稳态介质，包括免疫系统、肠道屏障功能和疾病易感性途径。因此，维持或恢复微生物群和代谢物组成可能是针对危重疾病的治疗或预防目标。粪便微生物群移植和补充益生菌是基于微生物群的治疗方法，但在循证疗效方面存在一定局限性。本综述重点关注胃肠道生态系统与脓毒症之间相互作用的重要性，以强调新型微生物群靶向疗法，以改善脓毒症治疗的结果。