The etiology of cerebral microhemorrhages was further explored in the recently published observational cohort of 51 people who underwent 7T magnetic resonance imaging (MRI), as reported by Dr. Rotta et al. Using Quantitative Susceptibility Mapping of healthy elderly adults and adults with cerebral amyloid angiopathy (CAA) and hypertensive vasculopathy, the investigators observed a disproportionate burden of microbleeds with venous connections among patients with CAA vs control groups. This observation might suggest that some of these microbleeds have a venous origin. Although microbleeds in association with a venous connection represented a minority of microbleeds (only 14%), they were strongly tied to CAA over other conditions. Drs. Chen and Wang commented that cortical vessels may be mistaken for lobar microbleeds, leading to a misclassification bias. Furthermore, Drs. Chen and Wang observed a higher prevalence of deep microbleeds in association with a venous connection in their previous autopsy study. The investigators affirm that these results warrant validation using histopathology. Furthermore, one reason for their unique observations may be the higher sensitivity for detecting microbleeds when using an MRI with a greater magnet strength.

Rotta 等人报道，最近发表的 51 人接受了 7T 磁共振成像 (MRI) 的观察性队列进一步探讨了脑微出血的病因。使用健康老年人和患有脑淀粉样血管病 (CAA) 和高血压血管病的成年人的定量敏感性图谱，研究人员观察到 CAA 患者与对照组之间具有静脉连接的微出血负担不成比例。这一观察结果可能表明其中一些微出血起源于静脉。尽管与静脉连接相关的微出血占微出血的一小部分（仅 14%），但与其他情况相比，它们与 CAA 密切相关。博士 Chen 和 Wang 评论说，皮质血管可能被误认为是肺叶微出血，导致错误分类偏差。此外，博士。Chen 和 Wang 在之前的尸检研究中观察到与静脉连接相关的深部微出血的发生率较高。研究人员确认这些结果需要使用组织病理学进行验证。此外，他们独特观察的一个原因可能是在使用具有更大磁强度的 MRI 时检测微出血的灵敏度更高。