Purpose: 

The purpose of this study was to describe infectious interface keratitis after Descemet membrane endothelial keratoplasty (DMEK) more than 2 years after surgery.

Methods: 

A case study.

Results: 

In this study, we report a case of fungal infectious interface keratitis occurring 2 years after uncomplicated Descemet membrane endothelial keratoplasty. The donor corneal rim culture at the time of surgery grew a single colony of Candida albicans/dubliniensis, but the patient was not treated with antifungals at that time. At the onset of clinical infection, more than 2 years postoperatively, the patient was treated with systemic antifungals and adjuvant intrastromal amphotericin-B injection. The patient subsequently required penetrating keratoplasty with ultimately well-preserved visual acuity.

Conclusions: 

Fungal infectious interface keratitis (IIK) is a rare complication associated with lamellar keratoplasty. Although most common in the early postoperative period, this complication can occur several years after successful transplantation. Management may require a combination of systemic and stromal antifungal therapy. However, some patients may eventually require penetrating keratoplasty for definitive treatment.

中文翻译：

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后弹力层内皮角膜移植术后 2 年出现真菌感染性界面角膜炎

目的： 

本研究的目的是描述术后 2 年多后弹力层内皮角膜移植术 (DMEK) 后发生的感染性界面角膜炎。

方法： 

案例研究。

结果： 

在这项研究中，我们报告了一例在简单的后弹力层内皮角膜移植术后两年发生的真菌感染性界面角膜炎病例。手术时供体角膜边缘培养物生长出白色念珠菌/都柏林念珠菌的单个菌落，但当时患者未接受抗真菌药物治疗。术后2年多出现临床感染时，患者接受全身抗真菌药物和辅助基质内注射两性霉素-B。患者随后需要进行穿透性角膜移植术，最终视力得到良好保存。

结论： 

真菌感染性界面角膜炎（IIK）是一种与板层角膜移植术相关的罕见并发症。虽然最常见于术后早期，但这种并发症也可能在成功移植后几年发生。治疗可能需要结合全身抗真菌治疗和基质抗真菌治疗。然而，一些患者最终可能需要穿透性角膜移植术来进行彻底治疗。