Voiding dysfunction (VD) leading to urinary retention is a common neurogenic lower urinary tract symptom in multiple sclerosis (MS) patients. Currently, the only effective management for MS patients with VD is catheterization. Transcranial Rotating Permanent Magnet Stimulator (TRPMS) is a noninvasive, portable, multifocal neuromodulator that simultaneously modulates multiple cortical regions and the strength of their functional connections. In this pilot trial (ClinicalTrials.gov Identifier: NCT03574610), we investigated the safety and therapeutic effects of TRPMS in modulating brain regions of interest (ROI) engaged with voiding initiation to improve VD in MS women.

中文翻译：

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使用经颅旋转永磁刺激器对多发性硬化症女性的排尿功能障碍进行无创、个性化的皮层调节：一项试点试验。

导致尿潴留的排尿功能障碍 (VD) 是多发性硬化症 (MS) 患者常见的神经源性下尿路症状。目前，对患有 VD 的 MS 患者唯一有效的治疗方法是导管插入术。经颅旋转永磁刺激器 (TRPMS) 是一种无创、便携式、多焦点神经调节器，可同时调节多个皮质区域及其功能连接的强度。在这项试点试验（ClinicalTrials.gov 标识符：NCT03574610）中，我们研究了 TRPMS 在调节与开始排尿有关的大脑感兴趣区域 (ROI) 以改善 MS 女性 VD 的安全性和治疗效果。