Developing novel processing approaches is an effective way to improve the industrial utilization and production of crops. Dogwood (Cornus officinalis Sizb. et Zucc.) is an industrial crop in the Cornaceae family, which has been used as a traditional Chinese medicine with good medicinal values. Nevertheless, little is reported on the processing technology of C. officinalis products. In this study, we conducted a comprehensive study on the development and optimization of novel processing methods of C. officinalis fruits. The processing approach of fermentation was first used to obtain fruit extracts of C. officinalis. The fresh fruits and dried fruits were used as raw materials of fermentation. Three different parameters including sugar content, SO₂ addition and yeast inoculation were chosen as variables to determine the best fermentation condition using response surface methodology (RSM). The contents of total organic acids, total iridoid glycosides, and seven medicinal active ingredients were estimated to reveal the accumulation change of bioactive products during processing. The results showed that the main-fermentation time of fresh fruits is 12–16 days, and the after-fermentation time is 30–35 days, while the main-fermentation time of dried fruits is 16–20 days, and the after-fermentation time is 30–35 days. Compared with dry-fruit extracts, fresh-fruit extracts have better quality with higher contents of medicinal active ingredients. Collectively, these results provide valuable references for the processing of C. officinalis products. Moreover, the novel processing approaches of fermentation proposed in this study will shed light on further development of other medicinal crops.

开发新的加工方法是提高作物工业利用率和产量的有效途径。山茱萸（Cornus officinalis Sizb. et Zucc. ）是山茱萸科的经济作物，已被用作中药，具有良好的药用价值。然而，关于铁皮石斛产品加工技术的报道却很少。在本研究中，我们对厚朴果实的新型加工方法的开发和优化进行了全面研究。发酵处理方法首先用来获得的水果提取物C.巴戟. 以新鲜水果和干果为原料进行发酵。三个不同的参数，包括糖含量、SO ₂选择添加和酵母接种作为变量，以使用响应面方法 (RSM) 确定最佳发酵条件。估算总有机酸、总环烯醚萜苷和7种药用活性成分的含量，以揭示加工过程中生物活性产物的积累变化。结果表明：鲜果主发酵时间为12-16天，后发酵时间为30-35天，而干果主发酵时间为16-20天，后发酵时间为30-35天。时间是30-35天。与干果提取物相比，鲜果提取物质量更好，药用活性成分含量更高。总的来说，这些结果提供的处理提供有价值的参考C.巴戟产品。此外，本研究中提出的新型发酵加工方法将为其他药用作物的进一步开发提供启示。