Background

Although the assessment of right ventricular (RV) diastolic function is feasible, it has garnered far less momentum for use compared with its left ventricular counterpart. The scarcity of data defining normative RV diastolic function and the fact that implications of RV diastolic dysfunction in different disease states on outcomes are less well known both hinder integration into routine clinical assessment. The aim of this study was to establish normal values of RV diastolic parameters stratified by sex, age, and race using data from the World Alliance Societies of Echocardiography study.

Methods

A subset of 888 normal subjects from the World Alliance Societies of Echocardiography database were analyzed, including measurements of tricuspid valve (TV) inflow E- and A-wave velocities, E-wave deceleration time, and TV annular tissue Doppler e′ and a′ velocities. Additionally, right atrial (RA) maximal volume and RA peak reservoir strain were measured. Patients were grouped by age (<40, 41-65, and >65 years) and stratified by sex and race. Differences were analyzed using unpaired t tests.

Results

Compared with men, women had significantly higher TV e′ and E-wave and A-wave velocities, though differences were modest. Increasing age was associated with stepwise lower TV E wave, e′ velocity, and TV E/A ratio and higher a′ velocity and E/e′ ratio. RA peak reservoir strain was also lower, and RA end-systolic volume trended toward being smaller for older age groups. Asian subjects demonstrated significantly higher a′ velocities, lower E wave, the smallest RA end-systolic volumes, and the lowest RA peak strain values compared with white subjects of both sexes.

Conclusions

This study provides normal values for parameters used in the assessment of RV diastolic function stratified by race, sex, and age. The results demonstrate significant differences in RV diastolic parameters between age groups, which manifest in both individual parameters and composite ratios of TV inflow and annular velocities. Although limited sex- and race-related differences were also noted, age appears to have the most significant impact on RV diastolic parameters. These findings may aid in refining current normative values.

中文翻译：

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右心室舒张功能参数的性别、年龄和种族相关正常值：来自世界超声心动图研究联盟协会的数据

背景

尽管评估右心室 (RV) 舒张功能是可行的，但与左心室对应物相比，它获得的使用动力要少得多。缺乏定义规范 RV 舒张功能的数据，以及不同疾病状态下 RV 舒张功能障碍对结果的影响这一事实鲜为人知，这两者都阻碍了与常规临床评估的整合。本研究的目的是使用来自世界超声心动图联盟研究的数据建立按性别、年龄和种族分层的 RV 舒张参数的正常值。

方法

对来自世界超声心动图联盟数据库的 888 名正常受试者的子集进行了分析，包括三尖瓣 (TV) 流入 E 波和 A 波速度、E 波减速时间和 TV 环形组织多普勒 e' 和 a' 的测量值速度。此外，测量了右心房 (RA) 最大容积和 RA 峰值储层应变。患者按年龄（<40、41-65 和 >65 岁）分组，并按性别和种族分层。使用非配对t检验分析差异。

结果

与男性相比，女性的 TV e′、E 波和 A 波速度显着更高，但差异不大。年龄增加与逐步降低 TV E 波、e' 速度和 TV E/A 比以及更高的 a' 速度和 E/e' 比有关。RA 峰值储层应变也较低，并且年龄较大的 RA 收缩末期体积趋于更小。与两性的白人受试者相比，亚洲受试者表现出显着更高的 a' 速度、更低的 E 波、最小的 RA 收缩末期容积和最低的 RA 峰值应变值。

结论

本研究提供了用于评估按种族、性别和年龄分层的 RV 舒张功能的参数的正常值。结果表明，不同年龄组的 RV 舒张参数存在显着差异，这体现在个体参数以及 TV 流入和环速度的复合比率中。尽管还注意到与性别和种族相关的差异有限，但年龄似乎对 RV 舒张参数的影响最为显着。这些发现可能有助于完善当前的规范值。