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Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B
Hepatology ( IF 12.9 ) Pub Date : 2021-10-24 , DOI: 10.1002/hep.32210
Arshi Khanam 1 , Lydia S Y Tang 1, 2 , Shyam Kottilil 1
Affiliation  

Classical CD8 T cells are implicated for protective and pathogenic roles in chronic hepatitis B (CHB) infection. Recently, a subset of CD8 T cells expressing C-X-C chemokine receptor type 5 (CXCR5) and exhibiting features of TFH cells has been identified during chronic viral infections. However, in CHB, knowledge of their roles is limited.

中文翻译:


表达CD8+CXCR5+滤泡T细胞的程序性死亡1构成慢性乙型肝炎患者的效应细胞而非穷举表型



经典 CD8 T 细胞在慢性乙型肝炎 (CHB) 感染中发挥保护和致病作用。最近,在慢性病毒感染期间发现了表达 CXC 趋化因子受体 5 型 (CXCR5) 并表现出 T FH细胞特征的 CD8 T 细胞亚群。然而,在慢性乙型肝炎中,对其角色的了解有限。
更新日期:2021-10-24
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