ABSTRACT

Purpose

To determine the utility of routine screening ophthalmic exam in patients with systemic sarcoidosis and no history of uveitis.

Methods

Prospective, single-center, observational study conducted at Northwestern University from October 11, 2012 to October 1, 2020 of new patients with biopsy-proven systemic sarcoidosis and no history of uveitis, referred by medical subspecialists for screening ophthalmic exam.

Results

Forty-nine patients, with mean age of 51 ± 8.7 years, 59% female, 47% African American, 43% Caucasian, were enrolled. The majority (55%) had no ocular symptoms. The most common location of ocular involvement was the adnexa, in the form of conjunctival nodules (62%) and aqueous tear deficiency (23%). Intraocular inflammation was detected in 6 patients (13%); only 2 had active disease requiring treatment (4%). No asymptomatic patient had ocular involvement necessitating treatment.

Conclusion

Screening exams are indicated in sarcoidosis patients with ocular symptoms. No benefit of screening was demonstrated in asymptomatic patients.

中文翻译：

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筛查无症状眼部炎症在结节病中的作用

摘要

目的

确定常规筛查眼科检查对系统性结节病和无葡萄膜炎病史患者的效用。

方法

2012 年 10 月 11 日至 2020 年 10 月 1 日在西北大学进行的前瞻性、单中心、观察性研究，研究对象为经活检证实的系统性结节病且无葡萄膜炎病史的新患者，由医学专科医师转介进行眼科检查筛查。

结果

49 名患者，平均年龄为 51 ± 8.7 岁，59% 为女性，47% 为非裔美国人，43% 为高加索人。大多数 (55%) 没有眼部症状。最常见的眼部受累部位是附件，表现为结膜结节 (62%) 和泪液缺乏 (23%)。6 名患者 (13%) 检测到眼内炎症；只有 2 名患有需要治疗的活动性疾病 (4%)。没有无症状患者出现需要治疗的眼部受累。

结论

有眼部症状的结节病患者需要进行筛查。在无症状患者中没有证明筛查的益处。