We read with interest the commentary by Potjer highlighting the surveillance needs of individuals with a high risk of developing of pancreatic cancer (PC).1 The rationale in developing a comprehensive risk prediction model supporting earlier diagnosis is all the more valid given the poor prognosis and rising mortality of PC in many settings2 3 and the present gaps in our understanding of the underlying causes of the increase, as we highlight below. In 2020, approximately 466 000 PC deaths were estimated worldwide with considerable variations in rates by country and region (figure 1).4 The disease can be considered a major public health concern globally given it ranks within the top 10 leading types of cancer death in over 130 countries. Further, PC mortality is …

中文翻译：

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胰腺癌：日益严重的全球公共卫生问题

我们感兴趣地阅读了 Potjer 的评论，其中强调了胰腺癌 (PC) 发展风险高的个体的监测需求。1 鉴于预后不良和在许多环境中 PC 死亡率不断上升 2 3 以及我们目前对上升的根本原因的理解存在差距，如下文强调的那样。2020 年，估计全球约有 466,000 例 PC 死亡，不同国家和地区的死亡率差异很大（图 1）。4 该疾病可被视为全球主要的公共卫生问题，因为它在癌症死亡的前 10 位130多个国家。此外，PC 死亡率是……