We read with interest the commentary by Potjer highlighting the surveillance needs of individuals with a high risk of developing of pancreatic cancer (PC).1 The rationale in developing a comprehensive risk prediction model supporting earlier diagnosis is all the more valid given the poor prognosis and rising mortality of PC in many settings2 3 and the present gaps in our understanding of the underlying causes of the increase, as we highlight below. In 2020, approximately 466 000 PC deaths were estimated worldwide with considerable variations in rates by country and region (figure 1).4 The disease can be considered a major public health concern globally given it ranks within the top 10 leading types of cancer death in over 130 countries. Further, PC mortality is …

中文翻译：

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胰腺癌：日益严重的全球公共卫生问题


我们饶有兴趣地阅读了 Potjer 的评论，该评论强调了患有胰腺癌 (PC) 高风险个体的监测需求。1 鉴于预后不良和预后不良，开发支持早期诊断的综合风险预测模型的基本原理更加有效。 PC 死亡率在许多情况下不断上升2 3 以及目前我们对死亡率上升的根本原因的理解存在差距，如下文所强调。 2020 年，全球估计约有 466 000 例 PC 死亡，不同国家和地区的死亡率存在很大差异（图 1）。4 该疾病可被视为全球主要公共卫生问题，因为它位居全球十大主要癌症死亡类型之列。 130 多个国家。此外，PC 死亡率是……