Lippia origanoides and L. graveolens are natural sources of essential oils and compounds with bioactivity (e.g., flavonoids). The objective of this work was to model the extraction of L. graveolens and carvacrol-, thymol-, and phellandrene-rich chemotypes of L. origanoides using ethanol-modified supercritical CO₂ as the solvent using the Broken-and-Intact Cells (BIC) and Shrinking Core (SC) models. We studied the effects of the substrate and its pretreatment (grinding versus pelletization) and extraction conditions on extraction rate and yield. Model parameters for the BIC (fraction of broken cells, partition coefficient, and microstructural factor) and SC (microstructural factor) models were best-fitted to experimental cumulative extraction curves. Pelletizing favored rupture of inner cells, but made part of the oleoresin unavailable for extraction, partially due to thermal damage. SC was appropriate only for pelletized substrate, because it hypothesizes an interconnected porous space filled with condensed oleoresin, whereas that BIC was much better for the extraction of ground substrates.

过江藤origanoides和L.天竺葵是精油和与生物活性（的化合物的天然来源例如，黄酮类化合物）。这项工作的目的是模拟L.提取天竺葵和carvacrol-，L.的thymol-，和富水芹烯，化学型origanoides使用乙醇改性的超临界二氧化碳₂使用破碎和-完整细胞作为溶剂（BIC ) 和收缩核心 (SC) 模型。我们研究了基材及其预处理的影响（研磨与造粒）和提取条件对提取率和收率的影响。BIC（破碎细胞分数、分配系数和微观结构因子）和 SC（微观结构因子）模型的模型参数最适合实验累积提取曲线。造粒有利于内细胞的破裂，但会使部分油树脂无法提取，部分原因是热损伤。SC 仅适用于颗粒状基材，因为它假设一个相互连接的多孔空间充满凝聚的油性树脂，而 BIC 更适合提取研磨的基材。