IMPORTANCE Clinicians may rely on recommendations from clinical practice guidelines for management of patients. OBSERVATIONS A clinical practice guideline is a published statement that includes recommendations that are intended to optimize patient care. In the guideline development process, a panel of experts formulates recommendation questions that guide the retrieval of evidence that is used to inform the recommendations. Typically, methods of guideline development, a summary of the supporting evidence, and a justification of the panel's decisions accompany the recommendations. To use such guidelines optimally, clinicians must understand the implications of the recommendations, assess the trustworthiness of the development process, and evaluate the extent to which the recommendations are applicable to patients in their practice settings. Helpful recommendations are clear and actionable, and explicitly specify whether they are strong or weak, are appropriate for all patients, or depend on individual patients' circumstances and values. Rigorous guidelines and recommendations are informed by appropriately conducted, up-to-date systematic reviews that consider outcomes important to patients. Because judgments are involved in the interpretation of the evidence and the process of moving from evidence to recommendations, useful guidelines consider all relevant factors that have a bearing in a clinical decision and are not influenced by conflicts of interest. CONCLUSIONS AND RELEVANCE In considering a guideline's recommendations, clinicians must decide whether there are important differences between the factors the guideline panel has considered in making recommendations and their own practice setting.

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如何解释和使用临床实践指南或建议：医学文献用户指南。

重要性 临床医生可能会依赖临床实践指南中的建议来管理患者。观察 临床实践指南是一份已发表的声明，其中包括旨在优化患者护理的建议。在指南制定过​​程中，专家小组制定推荐问题，指导检索用于为推荐提供信息的证据。通常，指南制定的方法、支持性证据的总结以及专家组决定的理由都伴随着推荐。为了最佳地使用这些指南，临床医生必须了解建议的含义，评估开发过程的可信度，并评估建议在其实践环境中适用于患者的程度。有用的建议是明确且可操作的，并明确说明它们是强还是弱，是否适合所有患者，或取决于个别患者的情况和价值观。严格的指导方针和建议是通过适当进行的、最新的系统评价提供的，这些评价认为结果对患者很重要。由于判断涉及对证据的解释以及从证据到推荐的过程，因此有用的指南会考虑所有与临床决策相关且不受利益冲突影响的相关因素。结论和相关性 在考虑指南的建议时，