Introduction

Rheumatoid arthritis (RA) is related to cardiovascular disease and results in increased mortality rates. Ischemia, autonomic nervous system dysfunction, impaired cardiac ionic currents, and genetic predisposition may be the underlying mechanisms. Proarrhythmic ventricular electrophysiological remodeling detected on the basis of Tp‑e interval, Tp-e/QT, and Tp-e/QTc ratios plays a key role in the prognosis. Our aim was to assess proarrhythmic ventricular electrophysiological remodeling in patients with RA, a well-known chronic inflammatory disorder.

Materials and methods

A total of 163 patients with RA and 47 patients as a control group were included in this retrospective study. Proarrhythmic ventricular electrophysiological remodeling markers were evaluated in both groups along with baseline demographic and clinical variables. Patients using medication or with chronic disorders that can affect ventricular repolarization markers were excluded.

Results

The patients with RA had prolonged Tp‑e interval (66 ms [44–80]; 80 ms [78–96], p < 0.001) and increased Tp-e/QT ratio (0.18 [0.12–0.22]; 0.22 [0.20–0.24], p < 0.001) and Tp-e/QTc ratio (0.16 [0.11–0.19]; 0.20 [0.17–0.22], p < 0.001) compared to the control group.

Conclusion

The Tp‑e interval and Tp-e/QT ratio, which may help to clarify the pathophysiological mechanisms of ventricular arrhythmias, were increased in patients with RA.

中文翻译：

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类风湿性关节炎患者促心律失常心室电生理重构的评估

介绍

类风湿性关节炎 (RA) 与心血管疾病有关并导致死亡率增加。缺血、自主神经系统功能障碍、心脏离子电流受损和遗传易感性可能是潜在的机制。基于 Tp-e 间期、Tp-e/QT 和 Tp-e/QTc 比值检测的心律失常前心室电生理重构在预后中起关键作用。我们的目的是评估 RA（一种众所周知的慢性炎症性疾病）患者的致心律失常心室电生理重塑。

材料和方法

该回顾性研究共纳入 163 例 RA 患者和 47 例作为对照组的患者。在两组中评估了促心律失常心室电生理重构标志物以及基线人口统计学和临床​​变量。使用药物或患有可影响心室复极标志物的慢性疾病的患者被排除在外。

结果

RA 患者的 Tp-e 间期延长（66 ms [44-80]；80 ms [78-96]，p  < 0.001），Tp-e/QT 比值增加（0.18 [0.12-0.22]；0.22 [0.20] –0.24], p  < 0.001) 和 Tp-e/QTc 比值 (0.16 [0.11–0.19]; 0.20 [0.17–0.22], p  < 0.001) 与对照组相比。

结论

RA 患者的 Tp-e 间期和 Tp-e/QT 比值可能有助于阐明室性心律失常的病理生理机制。