Introduction

Although degenerative mitral valve disease (DMVD) is essentially a disorder of the valve, the progression of the disease leads to structural myocardial changes that may compromise left ventricular systolic function. Tissue motion annular displacement (TMAD) is a surrogate for longitudinal fiber function based on speckle tracking assessment of the movement of the mitral annulus toward the apex during systole. The aim of this study was to evaluate longitudinal systolic function with TMAD in dogs with DMVD.

Animals

Ninety-four dogs with DMVD and 32 healthy dogs.

Methods

Prospective cross-sectional observational study. Dogs with DMVD of various American College of Veterinary Internal Medicine classification stages and healthy control dogs underwent physical examination, electrocardiography, systolic blood pressure measurement, as well as a standard and speckle tracking echocardiography. Global longitudinal strain (GLS) and TMAD were used to assess longitudinal systolic function.

Results

The global TMAD_mm and global TMAD_% were higher in American College of Veterinary Internal Medicine B2 animals than in the stage CD. Global TMAD _(mm/kg,_mm/$\sqrt[3]{\text{bodyweight}}$, _mm/m²) were correlated with GLS and ejection fraction. Global TMAD _(mm/kg,_mm/m²,%) and GLS were influenced by sex. In addition, systolic blood pressure influenced GLS (P < 0.01; r = −0.23), global TMAD_mm/kg (P = 0.017; r = −0.21) and global TMAD_mm/m² (P = 0.031; r = −0.19). Tissue motion annular displacement was fast to be performed and produced good repeatability in dogs with DMVD.

Conclusions

Global TMAD _(mm,%), was reduced in DMVD dogs with clinical signs of heart failure compared with stage B2. Tissue motion annular displacement was shown to be a repeatable technique for evaluation of longitudinal systolic function in dogs with DMVD.

中文翻译：

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使用组织运动环状位移评估患有退行性二尖瓣疾病的犬的纵向收缩功能

介绍

尽管退行性二尖瓣疾病 (DMVD) 本质上是一种瓣膜疾病，但疾病的进展会导致结构性心肌变化，这可能会损害左心室收缩功能。组织运动环位移 (TMAD) 是纵向纤维功能的替代品，它基于对收缩期二尖瓣环向心尖移动的散斑跟踪评估。本研究的目的是在患有 DMVD 的狗中评估 TMAD 的纵向收缩功能。

动物

94 只患有 DMVD 的狗和 32 只健康狗。

方法

前瞻性横断面观察研究。美国兽医内科医学院各种分类阶段的 DMVD 犬和健康对照犬接受了身体检查、心电图、收缩压测量以及标准和斑点跟踪超声心动图。全局纵向应变 (GLS) 和 TMAD 用于评估纵向收缩功能。

结果

美国兽医内科医学院 B2 动物的整体 TMAD _mm和整体 TMAD _%高于 CD 阶段。全球 TMAD _(mm/kg , _mm/$\sqrt[3]{\text{体重}}$, _{mm/m ² )}与 GLS 和射血分数相关。全球 TMAD _(mm/kg , _{mm/m ² ,%)}和 GLS 受性别影响。此外，收缩压影响 GLS（P < 0.01；r = -0.23）、整体 TMAD _mm/kg（P = 0.017；r = -0.21）和整体 TMAD _{mm/m ²}（P = 0.031；r = -0.19 ）。组织运动环形位移可以快速执行，并在 DMVD 狗身上产生良好的可重复性。

结论

与 B2 期相比，具有心力衰竭临床症状的 DMVD 犬的总体 TMAD _(mm,%)降低。组织运动环状位移被证明是一种可重复的技术，用于评估患有 DMVD 的狗的纵向收缩功能。