Smart Nanogatekeepers for Tumor Theranostics,Small

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Smart Nanogatekeepers for Tumor Theranostics
Small ( IF 13.0 ) Pub Date : 2021-10-22 , DOI: 10.1002/smll.202103712
Xunfa Zhang ₁ , Yang Chen ₂ , Xian He _{1,

3} , Yachao Zhang _{1,

3} , Mei Zhou ₁ , Chengjun Peng _{1,

3} , Zhonggui He ₄ , Shuangying Gui _{1,

3} , Zhenbao Li _{1,

3}

Affiliation

Nanoparticulate drug delivery systems (nano-DDSs) are required to reliably arrive and persistently reside at the tumor site with minimal off-target side effects for clinical theranostics. However, due to the complicated environment and high interstitial pressure in tumor tissue, they can return to the bloodstream and cause secondary side effects in normal organs. Recently, a number of nanogatekeepers have been engineered via structure-transformable/stable strategies to overcome this undesirable dilemma. The emerging structure-transformable nanogatekeepers for tumor imaging and therapy are first overviewed here, particularly for nanogatekeepers undergoing structural transformation in tumor microenvironments, cell membranes, and organelles. Thereafter, intelligent structure-stable nanogatekeepers through reversible activation and artificial individualization receptors are overviewed. Finally, the ongoing challenges and prospects of nanogatekeepers for clinical translation are briefly discussed.

中文翻译：

用于肿瘤治疗的智能纳米门卫

纳米颗粒给药系统 (nano-DDSs) 需要可靠地到达并持续存在于肿瘤部位，同时将临床治疗诊断的脱靶副作用降至最低。但由于肿瘤组织环境复杂，间质压力高，可返回血流，对正常器官造成继发性副作用。最近，通过结构可转换/稳定策略设计了许多纳米守门员，以克服这种不利的困境。本文首先概述了用于肿瘤成像和治疗的新兴结构可转换纳米守门人，特别是在肿瘤微环境、细胞膜和细胞器中进行结构转化的纳米守门人。此后，概述了通过可逆激活和人工个体化受体的智能结构稳定纳米看门人。最后，简要讨论了纳米看门人在临床翻译方面的持续挑战和前景。

更新日期：2021-11-25

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