Mutational signatures can shed light onto mechanisms of carcinogenesis and reveal the mutagenic impact of novel and established environmental risk factors. A new study examines the mutational spectra of esophageal squamous cell cancer together with exposure information in regions of high and low incidence of the disease, and demonstrates both the limitations and potential of mutational signature analyses.

中文翻译：

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全球食道癌突变特征

突变特征可以揭示致癌机制，并揭示新的和已确定的环境风险因素的诱变影响。一项新研究检查了食管鳞状细胞癌的突变谱以及该疾病高发和低发区域的暴露信息，并证明了突变特征分析的局限性和潜力。