Uncontrolled stress can lead to vascular injury, hypertension, arrhythmia, compromised immune system alteration in microbiota activity, and neurobehavioral changes, including depression. The gut microbiota has been recently developed, not only for major depressive disorders but also cardiovascular problems, as a therapeutic concern. Since then, >100 studies have studied the link between depression and cardiovascular disease (CVD), and have shown that depression is common (≈20%–35%) in patients with CVD, and seems to be indicative of negative heart effects in patients. Depressive symptoms patients have demonstrated an elevated platelet reactivity, reduced cardiac variability, and enhanced proinflammatory signals, which are all cardiovascular-related risk factors. The pathophysiology of depression-related CVD is nevertheless a challenge because of the heterogeneous depressive syndromes and the etiologies. The cardiovascular effects of tetrahydrocannabinol (THC) (the key psychotropic credential of cannabis) and endocannabinoids (THC endogenous equivalents which cause type 1 [CB1] and 2 [CB2] cannabinoids) have been extensively examined based on well-documented effects of marijuana smoke on blood pressure (BP) and heart rate (HR). Therefore, the aim of the review article is to establish the relationship of abnormal cannabidiols system-mediated cardiovascular protection in disrupted gut/brain axis associated depression to determine the translational potential of targeting abnormal cannabidiols receptors in clinical studies.

中文翻译：

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异常大麻二酚系统介导的对肠/脑轴受损相关抑郁症的心血管保护的研究

不受控制的压力会导致血管损伤、高血压、心律失常、微生物群活动的免疫系统改变受损以及神经行为改变，包括抑郁症。肠道微生物群最近被开发出来，不仅用于治疗重度抑郁症，还用于治疗心血管问题，作为一种治疗关注点。从那时起，超过 100 项研究研究了抑郁症和心血管疾病 (CVD) 之间的联系，并表明抑郁症在 CVD 患者中很常见 (≈20%–35%)，并且似乎表明患者对心脏有负面影响. 抑郁症状患者的血小板反应性升高、心脏变异性降低和促炎信号增强，这些都是心血管相关的危险因素。然而，由于抑郁综合征和病因的异质性，抑郁相关 CVD 的病理生理学仍然是一个挑战。四氢大麻酚 (THC)（大麻的关键精神药物）和内源性大麻素（导致 1 型 [CB1] 和 2 型 [CB2] 大麻素的 THC 内源性等效物）的心血管影响已根据有据可查的大麻烟雾对心血管的影响进行了广泛的研究。血压（BP）和心率（HR）。因此，这篇综述文章的目的是建立异常大麻二酚系统介导的心血管保护在肠/脑轴受损相关抑郁症中的关系，以确定在临床研究中靶向异常大麻二酚受体的转化潜力。四氢大麻酚 (THC)（大麻的关键精神药物）和内源性大麻素（导致 1 型 [CB1] 和 2 型 [CB2] 大麻素的 THC 内源性等效物）的心血管影响已根据有据可查的大麻烟雾对心血管的影响进行了广泛的研究。血压（BP）和心率（HR）。因此，这篇综述文章的目的是建立异常大麻二酚系统介导的心血管保护在肠/脑轴受损相关抑郁症中的关系，以确定在临床研究中靶向异常大麻二酚受体的转化潜力。四氢大麻酚 (THC)（大麻的关键精神药物）和内源性大麻素（导致 1 型 [CB1] 和 2 型 [CB2] 大麻素的 THC 内源性等效物）的心血管影响已根据有据可查的大麻烟雾对心血管的影响进行了广泛的研究。血压（BP）和心率（HR）。因此，这篇综述文章的目的是建立异常大麻二酚系统介导的心血管保护在肠/脑轴受损相关抑郁症中的关系，以确定在临床研究中靶向异常大麻二酚受体的转化潜力。