Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study,American Journal of Ophthalmology

当前位置： X-MOL 学术 › Am. J. Ophthalmol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study
American Journal of Ophthalmology ( IF 4.1 ) Pub Date : 2021-10-22 , DOI: 10.1016/j.ajo.2021.10.008
Matthias M Mauschitz ₁ , Marie-Therese Schmitz ₂ , Timo Verzijden ₃ , Matthias Schmid ₂ , Eric F Thee ₃ , Johanna M Colijn ₃ , Cécile Delcourt ₄ , Audrey Cougnard-Grégoire ₄ , Bénédicte M J Merle ₄ , Jean-François Korobelnik ₄ , Bamini Gopinath ₅ , Paul Mitchell ₆ , Hisham Elbaz ₇ , Alexander K Schuster ₈ , Philipp S Wild ₉ , Caroline Brandl ₁₀ , Klaus J Stark ₁₁ , Iris M Heid ₁₁ , Felix Günther ₁₂ , Annette Peters ₁₃ , Caroline C W Klaver ₁₄ , Robert P Finger ₁ ,

Affiliation

Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany.
Department of Medical Biometry, Informatics and Epidemiology (M.-T.S., M.S.), Medical Faculty, University of Bonn, Bonn, Germany.
Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands.
Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia; Department of Linguistics (B.G.,), Macquarie University Hearing, Macquarie University, Sydney, New South Wales, Australia.
Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Department of Ophthalmology (H.E.), Otto-von-Guericke University, Magdeburg, Germany.
Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Preventive Cardiology and Preventive Medicine, Center for Cardiology (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; DZHK (German Center for Cardiovascular Research) (P.S.W.), partner site Rhine-Main, Mainz, Germany.
Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Department of Ophthalmology (C.B.), University Hospital Regensburg, Regensburg, Germany.
Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany.
Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Statistical Consulting Unit StaBLab, Department of Statistics (F.G.), Ludwig-Maximilians-University Munich, Germany.
Institute of Epidemiology (A.P.), Helmholtz Center Munich, Germany; Department of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology (A.P.), Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Opthalmology (C.C.W.K.), Radboudumc, Nijmegen, the Netherlands; Institute of Molecular and Clinical Ophthalmology (C.C.W.K.), Basel, Switzerland.

PURPOSE

To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population.

DESIGN

Meta-analysis of longitudinal cohort studies.

METHODS

We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD.

RESULTS

At baseline, mean age was 60.7 ± 6.9 to 76.4 ± 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD.

CONCLUSIONS

Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact.

中文翻译：

年龄相关性黄斑变性的体力活动、发病率和进展：一项多队列研究

目的

调查体育活动 (PA) 对一般人群中年龄相关性黄斑变性 (AMD) 发病率或进展的影响。

设计

纵向队列研究的荟萃分析。

方法

我们从 7 项基于人群的研究中纳入了 14,630 名基线时没有或早期 AMD 的成年人，并使用每项研究的多态模型 (MSM) 和随后的随机效应荟萃分析检查了 PA 与 AMD 发病率和进展的关联。使用元回归评估年龄效应。主要结果测量是早期事件或进展为晚期 AMD 的风险比 (HR)。

结果

基线时，平均年龄为 60.7 ± 6.9 至 76.4 ± 4.3 岁，早期 AMD 的患病率为 7.7%（范围为 3.6%-16.9%）。在随访期间，早期和晚期 AMD 分别发生了 1461 和 189 起事件。在荟萃分析中，无或低至中度 PA（高 PA 作为参考）与早期 AMD 事件的风险增加相关（HR，1.19；95% CI，1.01-1.40；P = .04），但对于晚期不相关AMD。在随后的元回归中，我们发现年龄与 PA 对事件 AMD 的影响没有关联。