Food Chemistry ( IF 8.5 ) Pub Date : 2021-10-21 , DOI: 10.1016/j.foodchem.2021.131444 Ali Ali Redha 1 , Hamidreza Valizadenia 2 , Shahida Anusha Siddiqui 3 , Sajid Maqsood 4
The generation of camel milk derived bioactive peptides (CMPs) have started to grab keen interest of many researchers during the past decade. CMPs have shown more significant bioactive properties in comparison to camel milk intact proteins. CMPs can be obtained using enzyme hydrolysis to form hydrolysates, or by the fermentation process. In this systematic review, 46 research articles exploring the health-related bioactive properties of CMPs through in-vitro and in-vivo studies have been included. CMPs have been reported for their antioxidant, anti-diabetic, anti-obesity, antihypertensive, antibacterial, antibiofilm, anticancer, anti-inflammatory, anti-haemolytic, and anti-hyperpigmentation activities. The effects of factors such as molecular weight of peptides, type of enzyme, enzyme to substrate ratio, hydrolysis temperature and duration have been analysed. The in-vitro studies have provided enough evidence on certain aspects of the pharmacological actives of camel milk bioactive peptides. Nevertheless, the in-vivo studies are very limited, and no clinical studies on CMPs have been reported.
中文翻译:
对骆驼奶蛋白作为具有多种营养特性的生物活性肽的新兴来源的最新评论
在过去的十年中,骆驼奶衍生的生物活性肽 (CMP) 的产生引起了许多研究人员的浓厚兴趣。与骆驼奶完整蛋白质相比,CMP 显示出更显着的生物活性特性。可以使用酶水解形成水解物或通过发酵过程获得 CMP。这篇系统综述收录了 46 篇通过体外和体内研究探索 CMP 与健康相关的生物活性特性的研究文章。据报道,CMP 具有抗氧化、抗糖尿病、抗肥胖、抗高血压、抗菌、抗生物膜、抗癌、抗炎、抗溶血和抗色素沉着过度的活性。肽的分子量、酶的类型、酶与底物的比例等因素的影响,分析了水解温度和持续时间。体外研究为骆驼奶生物活性肽的药理活性的某些方面提供了足够的证据。然而,体内研究非常有限,并且没有关于 CMP 的临床研究的报道。