IL-23 is a cytokine member of the IL-12 superfamily. These heterodimeric cytokines offer broad immune regulatory activity with potential effector function in inflammatory arthritis. IL-23 is a pro-inflammatory cytokine secreted by dendritic cells and macrophages. It plays a key role in both innate and adaptive immunity. By promoting and maintaining T cell differentiation into Th17 T cells, IL-23 is a key player in the pathogenesis of rheumatic diseases. Data from pre-clinical IL-23 knockout models show the major importance of IL-23 in development of arthritis. The induction and maintenance of type 17 cells, which secrete IL-17A and other pro-inflammatory cytokines, contributes to local synovial inflammation and skin inflammation in PsA, and perhaps in RA. Commensurate with this, therapeutic strategies targeting IL-23 have proven efficient in PsA in several studies, albeit not yet in RA.

中文翻译：

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IL-23 在关节炎中协调免疫细胞激活

IL-23 是 IL-12 超家族的细胞因子成员。这些异二聚体细胞因子提供广泛的免疫调节活性，在炎症性关节炎中具有潜在的效应功能。IL-23 是一种由树突状细胞和巨噬细胞分泌的促炎细胞因子。它在先天性和适应性免疫中都起着关键作用。通过促进和维持 T 细胞分化为 Th17 T 细胞，IL-23 是风湿性疾病发病机制中的关键参与者。来自临床前 IL-23 敲除模型的数据显示 IL-23 在关节炎发展中的重要性。分泌 IL-17A 和其他促炎细胞因子的 17 型细胞的诱导和维持有助于 PsA 和 RA 中的局部滑膜炎症和皮肤炎症。与此相称，