The role of mprF mutations in “see-saw effect” of Daptomycin-resistant methicillin-resistant Staphylococcus aureus isolates,Antimicrobial Agents and Chemotherapy

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The role of mprF mutations in “see-saw effect” of Daptomycin-resistant methicillin-resistant Staphylococcus aureus isolates
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-10-18 , DOI: 10.1128/aac.01295-21
Shengnan Jiang _{1,

2} , Hemu Zhuang _{1,

2} , Feiteng Zhu _{1,

2} , Xiang Wei _{2,

3} , Junxiong Zhang _{1,

4} , Lu Sun _{1,

2} , Shujuan Ji _{1,

2} , Haiping Wang _{1,

2} , Dandan Wu ₅ , Feng Zhao ₆ , Rushuang Yan _{1,

2} , Yunsong Yu _{1,

2} , Yan Chen _{1,

2}

Affiliation

The emergence of daptomycin-resistant (DAP-R) Staphylococcus aureus strains has become a global problem. Point mutations in mprF are the main cause of daptomycin (DAP) treatment failure. However, the impact of these specific point-mutations in methicillin-...

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