Sex-Specific Neurotoxicity of Dietary Advanced Glycation End Products in APP/PS1 Mice and Protective Roles of Trehalose by Inhibiting Tau Phosphorylation via GSK-3β-TFEB,Molecular Nutrition & Food Research

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Sex-Specific Neurotoxicity of Dietary Advanced Glycation End Products in APP/PS1 Mice and Protective Roles of Trehalose by Inhibiting Tau Phosphorylation via GSK-3β-TFEB
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-10-20 , DOI: 10.1002/mnfr.202100464
Huan-Huan Zhou ₁ , Lan Luo ₁ , Xue-Di Zhai ₁ , Liangkai Chen ₂ , Guiping Wang ₃ , Li-Qiang Qin ₁ , Zengli Yu ₄ , Li-Li Xin ₁ , Zhongxiao Wan _{1,

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Affiliation

It remains unclear whether dietary advanced glycation end products (dAGEs)-induced cognitive impairment is sex-dependent. Trehalose may antagonize dAGEs-induced neurotoxicity via glycogen synthase kinase-3 beta (GSK3β)-transcription factor EB (TFEB) signaling.

中文翻译：

APP/PS1 小鼠膳食高级糖化终产物的性别特异性神经毒性和海藻糖通过 GSK-3β-TFEB 抑制 Tau 磷酸化的保护作用

目前尚不清楚膳食晚期糖基化终产物 (dAGEs) 诱导的认知障碍是否具有性别依赖性。海藻糖可通过糖原合酶激酶 3 β (GSK3β)-转录因子 EB (TFEB) 信号传导拮抗 dAGEs 诱导的神经毒性。

更新日期：2021-12-03

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