Aluminum phosphide (AlP) is commonly used as a powerful suicidal tool. The exact mechanism of acute toxicity has not been well defined despite high mortality rates as well as its supportive treatment including rapid decontamination and institution of resuscitative measures. The current study aimed to investigate a new combination therapy using trimetazidine, N-acetyl cysteine, vitamin C, and hyperinsulinemia–euglycemia to manage acute AlP poisoning. Acute AlP-induced cardiotoxicity, hemodynamic changes, and hepatotoxicity were evaluated using electrocardiogram, creatinine kinase MB iso-enzyme, troponin-1, blood pressure, random blood glucose level, liver function tests, and histopathological changes in both the heart and liver in a rabbit model of AlP poisoning. The results showed that the new regimen therapy ameliorates the toxic effect of AlP with significant improvement in survival, cardiovascular and hemodynamic parameters in addition to histopathological changes. These results highlight the strong cardioprotective, antioxidant, hepatoprotective effects of the new combined therapy along with correction of hemodynamic changes and hyperglycemia as a potential target in the management of acute AlP poisoning.

中文翻译：

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曲美他定与高胰岛素血症-高血糖、N-乙酰半胱氨酸和维生素 C：一种管理磷化铝中毒的新方法概念

磷化铝 (AlP) 通常用作强大的自杀工具。尽管死亡率很高以及包括快速去污和复苏措施在内的支持性治疗，急性毒性的确切机制仍未得到很好的定义。目前的研究旨在研究一种使用曲美他嗪、N-乙酰半胱氨酸、维生素 C 和高胰岛素血症 - 血糖正常以控制急性 AlP 中毒。使用心电图、肌酐激酶 MB 同工酶、肌钙蛋白-1、血压、随机血糖水平、肝功能测试和心脏和肝脏的组织病理学变化评估急性 AlP 诱导的心脏毒性、血流动力学变化和肝毒性。 AlP中毒的兔子模型。结果表明，新的方案疗法改善了 AlP 的毒性作用，除了组织病理学变化外，还显着改善了生存、心血管和血流动力学参数。这些结果突出了强心脏保护、抗氧化、