Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation of the nuclear factor E2-related factor 2–related antioxidative stress pathway. With recent progression of research on longevity, the beneficial effects of ketone bodies are being clarified, and a positive image of ketone bodies is gradually beginning to develop in many research fields including nephrology.

中文翻译：

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酮体：回到阳光下的地方

由于酮症酸中毒（一种危及生命的糖尿病并发症），酮体在医学上具有强烈的负面形象。然而，Fang等人。报道称，酮体在糖尿病条件下通过激活核因子 E2 相关因子 2 相关抗氧化应激途径在足细胞中发挥抗衰老作用。随着近年来长寿研究的进展，酮体的有益作用逐渐被阐明，酮体的积极形象在包括肾病学在内的许多研究领域逐渐开始发展。