Dickkopf-related protein 3 is a stress-induced, epithelial cell–derived glycoprotein that is promoted as a prognostic as well as a predictive urinary biomarker in acute and chronic kidney disease. Schunk et al. provided evidence that Dickkopf-related protein 3 identifies patients with chronic obstructive pulmonary disease and preserved kidney function at increased risk for a loss of estimated glomerular filtration rate and deterioration of pulmonary function. Experimental data highlighted Dickkopf-related protein 3–related pathophysiological similarities and interactions between chronic kidney disease and chronic obstructive pulmonary disease.

中文翻译：

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慢性肺病患者的尿 Dickkopf-3 与肾损伤

Dickkopf 相关蛋白 3 是一种应激诱导的、上皮细胞衍生的糖蛋白，在急性和慢性肾病中被推广为预后和预测尿液生物标志物。舒克等人。提供的证据表明，Dickkopf 相关蛋白 3 可识别患有慢性阻塞性肺疾病并保留肾功能的患者，其肾小球滤过率降低和肺功能恶化的风险增加。实验数据突出了 Dickkopf 相关蛋白 3 相关的病理生理学相似性和慢性肾病和慢性阻塞性肺病之间的相互作用。