Background

Patients with psoriasis have elevated risk of coronary artery disease.

Objective

Do patients with severe psoriasis have larger epicardial adipose tissue volumes (EAT-V) that are associated with cardiovascular risk?

Methods

For this cross-sectional study, we recruited dermatology patients with severe psoriasis and control patients without psoriasis or rheumatologic disease themselves or in a first-degree relative. Participants aged 34 to 55 years without known coronary artery disease or diabetes mellitus underwent computed tomography (CT); EAT-V was obtained from noncontrast CT heart images.

Results

Twenty-five patients with psoriasis (14 men, 11 women) and 16 controls (5 men, 11 women) participated. Groups had no statistical difference in age, body mass index, various cardiovascular risk factors (except high-sensitivity C-reactive protein in men), CT-determined coronary artery calcium scores or plaque, or family history of premature cardiovascular disease. Mean EAT-V was greater in the psoriasis group compared to controls (P = .04). There was no statistically significant difference among women; however, male patients with psoriasis had significantly higher EAT-V than controls (P = .03), even when corrected for elevated high-sensitivity C-reactive protein (P = .05).

Limitations

A single-center convenience sample may not be representative.

Conclusion

Males with psoriasis without known coronary disease or diabetes had greater EAT-V than controls. EAT-V may be an early identifier of those at increased risk for cardiovascular events.

中文翻译：

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患有严重银屑病的男性心外膜脂肪组织体积更大，这意味着心血管疾病风险增加：一项横断面研究

背景

银屑病患者患冠状动脉疾病的风险增加。

客观的

严重银屑病患者的心外膜脂肪组织体积 (EAT-V) 是否与心血管风险相关？

方法

在这项横断面研究中，我们招募了患有严重银屑病的皮肤病患者，以及本身没有银屑病或风湿病的对照患者或一级亲属。没有已知冠状动脉疾病或糖尿病的 34 至 55 岁的参与者接受了计算机断层扫描 (CT)；EAT-V 是从非对比 CT 心脏图像中获得的。

结果

25 名银屑病患者（14 名男性，11 名女性）和 16 名对照组（5 名男性，11 名女性）参加了研究。各组在年龄、体重指数、各种心血管危险因素（男性高敏 C 反应蛋白除外）、CT 确定的冠状动脉钙化评分或斑块或早发心血管疾病家族史方面没有统计学差异。与对照组相比，银屑病组的平均 EAT-V 更高（P  = .04）。女性之间没有统计学上的显着差异；然而，男性银屑病患者的 EAT-V 显着高于对照组 ( P  = .03)，即使校正高敏 C 反应蛋白升高 ( P  = .05) 也是如此。

限制

单中心便利样本可能不具有代表性。

结论

没有已知冠心病或糖尿病的银屑病男性患者的 EAT-V 高于对照组。EAT-V 可能是心血管事件风险增加的早期识别者。