Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics,Chemical Reviews

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-10-19 , DOI: 10.1021/acs.chemrev.1c00553
Yishen Liu _{1,

2} , Yang Li _{1,

2,

3} , Seyoung Koo ₄ , Yao Sun ₅ , Yixuan Liu ₁ , Xing Liu _{1,

6} , Yanna Pan ₂ , Zhiyun Zhang ₂ , Mingxia Du ₂ , Siyu Lu ₂ , Xue Qiao ₁ , Jianfeng Gao _{2,

7} , Xiaobo Wang ₈ , Zixin Deng _{1,

2} , Xianli Meng ₈ , Yuling Xiao _{1,

2,

3} , Jong Seung Kim ₄ , Xuechuan Hong _{1,

2}

Affiliation

State Key Laboratory of Virology, College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa 850000, China.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
Shenzhen Institute of Wuhan University, Shenzhen 518057, China.
Department of Chemistry, Korea University, Seoul 02841, Korea.
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Center of Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Laboratory of Plant Systematics and Evolutionary Biology, College of Life Science, Wuhan University, Wuhan 430072, China.
Center for Animal Experiment, Wuhan University, Wuhan 430071, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

In vivo imaging in the second near-infrared window (NIR-II, 1000–1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types of inorganic/organic fluorophores that can be used for noninvasive NIR-IIa/IIb imaging (NIR-IIa, 1300–1400 nm; NIR-IIb, 1500–1700 nm) with near-zero tissue autofluorescence and deeper tissue penetration. This review provides an overview of the reports published to date on the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. First, we summarize the design concepts of the up-to-date functional NIR-IIa/IIb biomaterials, in the order of single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), and organic fluorophores (OFs). Then, these novel imaging modalities and versatile biomedical applications brought by these superior fluorescent properties are reviewed. Finally, challenges and perspectives for future clinical translation, aiming at boosting the clinical application progress of NIR-IIa and NIR-IIb imaging technology are highlighted.

中文翻译：

多种类型的无机/有机 NIR-IIa/IIb 荧光团：从战略设计到分子成像和治疗诊断学

体内第二近红外窗口（NIR-II，1000-1700 nm）的成像使我们能够深入观察活体，为生物医学研究和临床应用创造了奇妙的机会。最近，跨学科研究热潮，重点是开发可用于无创 NIR-IIa/IIb 成像的多种无机/有机荧光团（NIR-IIa，1300-1400 nm；NIR-IIb，1500-1700 nm）具有接近零的组织自发荧光和更深的组织穿透。这篇综述概述了迄今为止发表的关于无机/有机 NIR-IIa/IIb 荧光团的设计、特性、分子成像和治疗诊断学的报告。首先，我们按照单壁碳纳米管（SWCNTs）的顺序总结了最新的功能性NIR-IIa/IIb生物材料的设计理念，量子点（QDs）、稀土掺杂纳米粒子（RENPs）和有机荧光团（OFs）。然后，回顾了这些优越的荧光特性带来的这些新颖的成像方式和多功能的生物医学应用。最后，强调了未来临床转化的挑战和前景，旨在促进 NIR-IIa 和 NIR-IIb 成像技术的临床应用进展。

更新日期：2021-10-19

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