Kinetic resolution of azaflavanones via a RuPHOX-Ru catalyzed asymmetric hydrogenation,Organic Chemistry Frontiers

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Kinetic resolution of azaflavanones via a RuPHOX-Ru catalyzed asymmetric hydrogenation
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-10-08 , DOI: 10.1039/d1qo01310f
Yue Zhu ₁ , Jiayu Zhou ₁ , Jing Li ₁ , Kai Xu ₂ , Jianxun Ye ₁ , Yufei Lu ₁ , Delong Liu ₁ , Wanbin Zhang _{1,

2}

Affiliation

The kinetic resolution of azaflavanones has been established via RuPHOX-Ru catalyzed asymmetric hydrogenation, providing chiral azaflavanones and azaflavanols in high yields with up to >20 : 1 dr and 99.7% ee. The highly efficient kinetic resolution process has been illustrated based on the deuterium labelling and racemization experiments. The reaction could be performed on a gram-scale with a relatively low catalyst loading (2000 S/C), and the resulting products allow for several transformations.

中文翻译：

通过 RuPHOX-Ru 催化的不对称氢化对氮杂黄烷酮进行动力学拆分

氮杂黄烷酮的动力学拆分是通过RuPHOX-Ru 催化的不对称氢化建立的，以高产率提供手性氮杂黄烷酮和氮杂黄烷醇，高达 >20:1 dr 和 99.7% ee。基于氘标记和外消旋化实验说明了高效的动力学拆分过程。该反应可以在克级规模上进行，催化剂负载量相对较低 (2000 S/C)，所得产物允许进行多次转化。

更新日期：2021-10-19

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