Chemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting and weakness. Regulated in Development and DNA Damage Response 1 (REDD1) is a stress-response protein that represses the mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1), and its expression is increased in models of muscle wasting. The aim of this study was to determine if deletion of REDD1 is sufficient to attenuate chemotherapy-induced muscle wasting and weakness in mice.

中文翻译：

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REDD1的缺失可防止化疗引起的小鼠肌肉萎缩和虚弱

化疗是对抗实体瘤和减轻转移的必要治疗方法。化疗会引起副作用，包括肌肉萎缩和虚弱。发育和 DNA 损伤反应调节 1 (REDD1) 是一种应激反应蛋白，可抑制复合物 1 (mTORC1) 中雷帕霉素 (mTOR) 的机械靶标，并且其在肌肉萎缩模型中的表达增加。本研究的目的是确定 REDD1 的缺失是否足以减轻化疗引起的小鼠肌肉萎缩和虚弱。