Alzheimer's disease (AD) is an unmet medical need worldwide, and physical inactivity is a risk factor for AD. Performing physical exercise is difficult at old age, and thus, decline in physical movement may be a cause of age-associated lowering of the brain function. This study aimed to elucidate the molecular mechanism and onset of the skeletal muscle atrophy-induced acceleration of AD.

中文翻译：

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骨骼肌萎缩诱导的血红素结合蛋白加速阿尔茨海默病认知障碍的发作

阿尔茨海默病 (AD) 是世界范围内未满足的医疗需求，缺乏运动是 AD 的危险因素。老年人进行体育锻炼很困难，因此，体育锻炼的下降可能是与年龄相关的大脑功能下降的原因。本研究旨在阐明骨骼肌萎缩诱发AD加速的分子机制和发病机制。