In this study, the serine biosynthetic enzyme PHGDH is shown to transition from the cytosol to the nucleus following nutrient stress. Nuclear PHGDH reduces local NAD+ availability needed for the PARylation of the transcription factor c-Jun. Consequently, c-Jun activity is reduced, contributing to sustained cancer cell proliferation.

中文翻译：

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核 PHGDH 保护癌细胞免受营养压力

在这项研究中，丝氨酸生物合成酶 PHGDH 显示在营养胁迫后从细胞质转变为细胞核。核 PHGDH 降低了转录因子 c-Jun PARylation 所需的局部 NAD+ 可用性。因此，c-Jun 活性降低，有助于癌细胞持续增殖。