General Tolerance of Galactosyltransferases toward UDP-galactosamine Expands Their Synthetic Capability,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

General Tolerance of Galactosyltransferases toward UDP-galactosamine Expands Their Synthetic Capability
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-18 , DOI: 10.1002/anie.202112574
Xuan Fu _{1,

2} , Madhusudhan Reddy Gadi ₁ , Shuaishuai Wang ₁ , Jinghua Han ₁ , Ding Liu ₁ , Xi Chen ₃ , Jun Yin _{1,

2} , Lei Li ₁

Affiliation

Preparation of diverse glycans is essential to glycobiology, while synthetically useful enzymes for this purpose are limited. This study discovered a general tolerance of galactosyltransferases (GalTs) toward uncommon donor UDP-galactosamine. A two-step strategy was devised to harness this property for the facile synthesis of GalNAc-glycosides.

中文翻译：

半乳糖基转移酶对 UDP-半乳糖胺的一般耐受性扩展了其合成能力

多种聚糖的制备对于糖生物学至关重要，而用于此目的的合成有用酶是有限的。这项研究发现半乳糖基转移酶 (GalTs) 对不常见的供体 UDP-半乳糖胺具有普遍耐受性。设计了一个两步策略来利用这一特性来轻松合成 GalNAc-糖苷。

更新日期：2021-12-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11