Chiral Heterogeneous Scandium Lewis Acid Catalysts for Continuous-Flow Enantioselective Friedel–Crafts Carbon–Carbon Bond-Forming Reactions,Angewandte Chemie International Edition

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Chiral Heterogeneous Scandium Lewis Acid Catalysts for Continuous-Flow Enantioselective Friedel–Crafts Carbon–Carbon Bond-Forming Reactions
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-18 , DOI: 10.1002/anie.202112797
Yuki Saito ₁ , Shū Kobayashi ₁

Affiliation

Chiral heterogeneous Sc catalysts that demonstrate excellent activity and selectivity for continuous-flow enantioselective Friedel–Crafts reactions of isatins with indoles have been developed. Noncovalent interactions between chiral Sc complexes and heteropoly acid-anchored amine-functionalized SiO₂ as support were utilized for the preparation. Continuous-flow synthesis of a biologically active compound was achieved by tuning the chiral ligands.

中文翻译：

手性多相钪路易斯酸催化剂用于连续流动对映选择性弗里德尔-克拉夫茨碳-碳键形成反应

已经开发出手性多相 Sc 催化剂，该催化剂在靛红与吲哚的连续流动对映选择性 Friedel-Crafts 反应中表现出优异的活性和选择性。手性Sc配合物和杂多酸锚定的胺官能化SiO ₂作为载体之间的非共价相互作用被用于制备。通过调整手性配体实现了生物活性化合物的连续流动合成。

更新日期：2021-12-06

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