The CO electrooxidation is long considered invincible in the proton exchange membrane fuel cell (PEMFC), where even a trace level of CO in H₂ seriously poisons the anode catalysts and leads to huge performance decay. Here, we describe a class of atomically dispersed IrRu-N-C anode catalysts capable of oxidizing CO, H₂, or a combination of the two. With a small amount of metal (24 μg_metal⋅cm⁻²) used in the anode, the H₂ fuel cell performs its peak power density at 1.43 W⋅cm⁻². When operating with pure CO, this catalyst exhibits its maximum current density at 800 mA⋅cm⁻², while the Pt/C-based cell ceases to work. We attribute this exceptional catalytic behavior to the interplay between Ir and Ru single-atom centers, where the two sites act in synergy to favorably decompose H₂O and to further facilitate CO activation. These findings open up an avenue to conquer the formidable poisoning issue of PEMFCs.

_{CO电氧化长期以来被认为在质子交换膜燃料电池（PEMFC）中是不可战胜的，其中即使H 2}中的微量CO也会严重毒化阳极催化剂并导致巨大的性能衰减。在这里，我们描述了一类原子分散的 IrRu-NC 阳极催化剂，能够氧化 CO、H ₂或两者的组合。在阳极使用少量金属（24 μg_金属·cm ^-2）时，H ₂燃料电池的峰值功率密度为 1.43 W·cm ^-2。当使用纯 CO 操作时，该催化剂在 800 mA·cm ^{-2时表现出最大电流密度}，而基于 Pt/C 的电池停止工作。我们将这种特殊的催化行为归因于 Ir 和 Ru 单原子中心之间的相互作用，这两个位点协同作用以有利地分解 H ₂ O 并进一步促进 CO 活化。这些发现为克服 PEMFC 的严重中毒问题开辟了一条途径。