Lactic acid (LA) is an essential commodity chemical, with bio-based LA ruling the market share. Macroalgae are a desirable feedstock for LA fermentation due to their high carbohydrate and low lignin content. Ulva sp., Gracilaria sp., and Sargassum cristaefolium were evaluated as a feedstock for LA fermentation. Mild acid-thermal hydrolysis (sulfuric acid concentrations < 5%) resulted in superior reducing sugar recovery. Gracilaria sp. attained maximum reducing sugar recovery (0.39 g/g biomass) and lactate yield (0.94 g/g). LA fermentation of fucose-rich hydrolysate of Sargassum cristaefolium is demonstrated for the first time, with 0.81 g/g LA yield and 0.36 g/g reducing sugars. Ulva sp. attained 0.21 g/g reducing sugars and 0.85 g/g LA yield. The efficiency of macroalgae for lactate bioconversion was in the order: red macroalgae > green macroalgae > brown macroalgae. L. rhamnosus and L. plantarum could efficaciously utilize seaweed sugars for LA production. Macroalgae can potentially replace lignocellulosic biomass as a feedstock in LA fermentation.

乳酸 (LA) 是一种必不可少的商品化学品，其中生物基 LA 占据市场份额。由于其高碳水化合物和低木质素含量，大型藻类是 LA 发酵的理想原料。Ulva sp.、Gracilaria sp. 和Sargassum cristaefolium被评估为 LA 发酵的原料。温和的酸热水解（硫酸浓度 < 5%）导致出色的还原糖回收率。江蓠属 达到最大还原糖回收率（0.39 g/g 生物量）和乳酸产量（0.94 g/g）。首次证明了海藻富含岩藻糖水解物的LA 发酵，LA 产量为 0.81 g/g，还原糖为 0.36 g/g。石莼sp. 达到 0.21 g/g 还原糖和 0.85 g/g LA 产率。大型藻类对乳酸生物转化的效率依次为：红色大型藻类>绿色大型藻类>棕色大型藻类。L. rhamnosus和L. plantarum可以有效地利用海藻糖生产 LA。大型藻类有可能取代木质纤维素生物质作为 LA 发酵的原料。