The transformation of fermentable sugars provided from lignocellulosic wastes into biofuels or bioproducts is a key point at second-generation biorefineries. Spent sulfite liquor is a xylose-rich hydrolysate constituting the main residue of sulfite mills producing dissolving cellulose. Due to the presence of the inhibitors in the spent liquor, the most promising valorization options require detoxification before sugars bioconversion.

In this work, a multi criteria analysis was implemented to select techno-economic and socio-environmental feasible detoxification alternatives that can be adapted to a wide variety of fermenting scenarios. Total inhibitors removal, phenolics removal, acetic acid removal, lignosulfonates removal, total sugar losses, fixed capital invested, manufacturing costs, waste toxicity, social acceptance, and employment were chosen as the most relevant criteria. The maximum allowable concentration of undesirable inhibitors cannot be established with a general character, and thereby decision-making tools result in feasible and efficient solutions. From a technical viewpoint best solution was anionic resins with a score of 0.68; the most economical alternative was the overliming with a score of 0.76; finally, from a socio-environmental perspective, overliming reached the highest score of 0.78. In addition, three spent liquor biorefinery models were proposed. Based on the multi-criteria analysis and based on the inhibitor's concentration affecting fermentation yields and productivity, the best detoxification alternatives were (1) anionic resins for polyhydroxyalkanoate production; (2) activated carbon for ethanol biorefinery; (3) overliming for xylitol biorefinery.

将木质纤维素废物提供的可发酵糖转化为生物燃料或生物产品是第二代生物精炼厂的关键点。亚硫酸盐废液是一种富含木糖的水解产物，是生产溶解纤维素的亚硫酸盐工厂的主要残留物。由于废液中存在抑制剂，最有希望的增值选择需要在糖生物转化之前进行解毒。

在这项工作中，实施了多标准分析，以选择可适用于各种发酵场景的技术经济和社会环境可行的解毒替代方案。选择总抑制剂去除、酚类去除、乙酸去除、木质素磺酸盐去除、总糖损失、固定资本投资、制造成本、废物毒性、社会接受度和就业作为最相关的标准。不需要的抑制剂的最大允许浓度不能用一般特征来确定，因此决策工具会产生可行和有效的解决方案。从技术角度来看，最佳解决方案是阴离子树脂，得分为 0.68；最经济的选择是过度使用，得分为 0.76；最后，从社会环境的角度来看，overliming 达到了最高分 0.78。此外，还提出了三种废液生物精炼模型。根据多标准分析和抑制剂浓度对发酵产量和生产力的影响，最佳解毒替代方案是 (1) 用于聚羟基链烷酸酯生产的阴离子树脂；(2) 乙醇生物炼制用活性炭；(3)木糖醇生物精炼的过度石灰。