Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study,Molecular Nutrition & Food Research

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Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-10-18 , DOI: 10.1002/mnfr.202100606
Raúl González-Domínguez _{1,

2} , Pol Castellano-Escuder _{1,

2,

3} , Francisco Carmona _{2,

3} , Sophie Lefèvre-Arbogast ₄ , Dorrain Y Low ₅ , Andrea Du Preez ₆ , Silvie R Ruigrok ₇ , Claudine Manach ₅ , Mireia Urpi-Sarda _{1,

2} , Aniko Korosi ₇ , Paul J Lucassen ₇ , Ludwig Aigner ₈ , Mercè Pallàs ₉ , Sandrine Thuret ₆ , Cécilia Samieri ₄ , Alex Sánchez-Pla _{2,

3} , Cristina Andres-Lacueva _{1,

2}

Affiliation

Biomarkers and Nutrimetabolomics Laboratory, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, 08028, Spain.
CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, Madrid, 28029, Spain.
Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, 08028, Spain.
University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.
Université Clermont Auvergne, INRAE, UNH, Clermont, Ferrand, F-63000, France.
Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.
Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, 1098 XH, The Netherlands.
Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, 5020, Austria.
Pharmacology Section, Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Barcelona, 08028, Spain.

Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent.

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