Chronic hepatitis C virus (HCV) infection is characterized by stable HCV RNA levels. Spontaneous clearance or even temporary control of viremia to undetectable levels are almost never observed in long-term chronic infection. Here we report the spontaneous control of HCV viremia in a patient following virological relapse with emergence of a NS5A drug-resistant virus after therapy with sofosbuvir and velpatasvir.

中文翻译：

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耐药性慢性丙型肝炎病毒感染的自发清除

慢性丙型肝炎病毒 (HCV) 感染的特征是稳定的 HCV RNA 水平。在长期慢性感染中几乎从未观察到病毒血症的自发清除甚至暂时控制到检测不到的水平。在这里，我们报告了一名患者在接受索非布韦和维帕他韦治疗后病毒学复发并出现 NS5A 耐药病毒后 HCV 病毒血症的自发控制。