Toolbox for Distal C–H Bond Functionalizations in Organic Molecules,Chemical Reviews

当前位置： X-MOL 学术 › Chem. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Toolbox for Distal C–H Bond Functionalizations in Organic Molecules
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-10-18 , DOI: 10.1021/acs.chemrev.1c00220
Soumya Kumar Sinha ₁ , Srimanta Guin ₁ , Sudip Maiti ₁ , Jyoti Prasad Biswas ₁ , Sandip Porey ₁ , Debabrata Maiti ₁

Affiliation

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted to take the help of this methodology to plan their synthetic discourses. This paradigm shift has helped in the development of industrial units as well, making the synthesis of natural products and pharmaceutical drugs step-economical. In the vast zone of C–H bond activation, the functionalization of proximal C–H bonds has gained utmost popularity. Unlike the activation of proximal C–H bonds, the distal C–H functionalization is more strenuous and requires distinctly specialized techniques. In this review, we have compiled various methods adopted to functionalize distal C–H bonds, mechanistic insights within each of these procedures, and the scope of the methodology. With this review, we give a complete overview of the expeditious progress the distal C–H activation has made in the field of synthetic organic chemistry while also highlighting its pitfalls, thus leaving the field open for further synthetic modifications.

中文翻译：

有机分子远端 C-H 键功能化工具箱

过渡金属催化的 C-H 活化已开发出一种当代方法来解决无所不在的逆合成断开领域。科学研究人员一直很想借助这种方法来计划他们的综合话语。这种范式转变也有助于工业单位的发展，使天然产物和药物的合成更加经济。在广大的 C-H 键活化区域中，近端 C-H 键的功能化得到了极大的普及。与近端 C-H 键的激活不同，远端 C-H 功能化更加费力，需要特别专业的技术。在这篇综述中，我们汇编了各种方法来功能化远端 C-H 键、每个程序中的机械见解以及方法的范围。

更新日期：2021-10-18

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11