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Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments
Hepatology ( IF 12.9 ) Pub Date : 2021-10-17 , DOI: 10.1002/hep.32201
Yutaka Kurebayashi 1 , Kosuke Matsuda 1 , Akihisa Ueno 1, 2 , Hanako Tsujikawa 1, 2 , Ken Yamazaki 1 , Yohei Masugi 1, 2 , Wit Thun Kwa 1 , Kathryn Effendi 1 , Yasushi Hasegawa 3 , Hiroshi Yagi 3 , Yuta Abe 3 , Minoru Kitago 3 , Hidenori Ojima 1 , Michiie Sakamoto 1
Affiliation  

Immune cells and tumor vessels constitute important elements in tumor tissue; however, their detailed relationship in human tumors, including HCC, is still largely unknown. Consequently, we expanded our previous study on the immune microenvironment of HCC and analyzed the relationship among the immune microenvironment, inflammatory/angiostatic factor expression, angiogenic factor expression, and tumor vessel findings, including vessels encapsulating tumor clusters (VETC) and macrotrabecular-massive (MTM) patterns.

中文翻译:

HCC 的免疫血管分类反映了免疫和血管生成肿瘤微环境之间的相互作用

免疫细胞和肿瘤血管构成肿瘤组织的重要成分;然而,它们在人类肿瘤(包括 HCC)中的详细关系在很大程度上仍然未知。因此,我们扩展了之前对 HCC 免疫微环境的研究,并分析了免疫微环境、炎症/血管抑制因子表达、血管生成因子表达和肿瘤血管发现之间的关系,包括血管包裹肿瘤簇 (VETC) 和巨小梁-肿块 ( MTM)模式。
更新日期:2021-10-17
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