Urban environment and cognitive and motor function in children from four European birth cohorts,Environment International

当前位置： X-MOL 学术 › Environ. Int. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Urban environment and cognitive and motor function in children from four European birth cohorts
Environment International ( IF 10.3 ) Pub Date : 2021-10-15 , DOI: 10.1016/j.envint.2021.106933
Anne-Claire Binter ₁ , Jonathan Y Bernard ₂ , Mark Mon-Williams ₃ , Ainara Andiarena ₄ , Llúcia González-Safont ₅ , Marina Vafeiadi ₆ , Johanna Lepeule ₇ , Raquel Soler-Blasco ₈ , Lucia Alonso ₁ , Mariza Kampouri ₉ , Rosie Mceachan ₁₀ , Loreto Santa-Marina ₁₁ , John Wright ₁₀ , Leda Chatzi ₁₂ , Jordi Sunyer ₁₃ , Claire Philippat ₇ , Mark Nieuwenhuijsen ₁ , Martine Vrijheid ₁ , Mònica Guxens ₁₄

Affiliation

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Spain.
Université de Paris, Centre for Research in Epidemiology and StatisticS (CRESS), Inserm, INRAE, F-75004 Paris, France; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore.
Bradford Institute for Health Research, Bradford, West Yorkshire, UK; School of Psychology, University of Leeds, Leeds, UK; National Centre for Optics, Vision and Eye Care, University of South-Eastern Norway, Kongsberg, Norway.
Faculty of Psychology, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain; Biodonostia, Environmental Epidemiology and Child Development Group, 20014 San Sebastian, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO -Universitat Jaume I -Universitat de Val ència, Valencia, Spain.
Department of Social Medicine, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece.
University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Grenoble, France.
Epidemiology and Environmental Health Joint Research Unit, FISABIO -Universitat Jaume I -Universitat de Val ència, Valencia, Spain.
Department of Social Medicine, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Bradford Institute of Health Research, Bradford BD9 6RJ, United Kingdom.
Epidemiology and Environmental Health Joint Research Unit, FISABIO -Universitat Jaume I -Universitat de Val ència, Valencia, Spain; Biodonostia, Epidemiology and Public Health Area, Environmental Epidemiology and Child Development Group, 20014 San Sebastian, Spain; Public Health Division of Gipuzkoa, Basque Government, 20013 San Sebastian, Spain.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, US.
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Spain; IMIM-Parc Salut Mar, Barcelona.
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Spain; Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.

Background

The urban environment may influence neurodevelopment from conception onwards, but there is no evaluation of the impact of multiple groups of exposures simultaneously. We investigated the association between early-life urban environment and cognitive and motor function in children.

Methods

We used data from 5403 mother–child pairs from four population-based birth-cohorts (UK, France, Spain, and Greece). We estimated thirteen urban home exposures during pregnancy and childhood, including: built environment, natural spaces, and air pollution. Verbal, non-verbal, gross motor, and fine motor functions were assessed using validated tests at five years old. We ran adjusted multi-exposure models using the Deletion-Substitution-Addition algorithm.

Results

Higher greenness exposure within 300 m during pregnancy was associated with higher verbal abilities (1.5 points (95% confidence interval 0.4, 2.7) per 0.20 unit increase in greenness). Higher connectivity density within 100 m and land use diversity during pregnancy were related to lower verbal abilities. Childhood exposure to PM2.5 mediated 74% of the association between greenness during childhood and verbal abilities. Higher exposure to PM2.5 during pregnancy was related to lower fine motor function (-1.2 points (-2.1, -0.4) per 3.2 μg/m3 increase in PM2.5). No associations were found with non-verbal abilities and gross motor function.

Discussion

This study suggests that built environment, greenness, and air pollution may impact child cognitive and motor function at five years old. This study adds evidence that well-designed urban planning may benefit children’s cognitive and motor development.

中文翻译：

来自四个欧洲出生队列的儿童的城市环境以及认知和运动功能

背景

城市环境可能会从受孕开始影响神经发育，但没有同时评估多组暴露的影响。我们调查了早期城市环境与儿童认知和运动功能之间的关系。

方法

我们使用了来自四个基于人口的出生队列（英国、法国、西班牙和希腊）的 5403 对母子的数据。我们估计了怀孕和儿童时期的 13 次城市家庭暴露，包括：建筑环境、自然空间和空气污染。在五岁时使用经过验证的测试评估语言、非语言、粗大运动和精细运动功能。我们使用删除-替换-加法算法运行调整后的多重曝光模型。

结果

怀孕期间 300 m 内较高的绿色暴露与较高的语言能力相关（绿色每增加 0.20 个单位，1.5 分（95% 置信区间 0.4, 2.7））。100 m 内较高的连通性密度和怀孕期间的土地利用多样性与较低的语言能力有关。儿童期 PM2.5 暴露介导了儿童期绿色与语言能力之间 74% 的关联。怀孕期间较高的 PM2.5 暴露与较低的精细运动功能有关（PM2.5 每增加 3.2 μg/m3，-1.2 点（-2.1，-0.4））。没有发现与非语言能力和粗大运动功能相关。