Dynamic inorganic nanoassemblies (DINAs) have emerged as smart nanomedicine platforms with promising potential for bioimaging and targeted drug delivery. In this review, we keep abreast of the advances in development of tumor microenvironment (TME)-responsive DINAs to meet the challenges associated with precise cancer therapy. TME-responsive DINAs are designed to achieve precise switches of structures/functions in response to TME-specific stimuli including reactive oxygen species (ROS), reduced pH and hypoxia, so as to enhance the tumor accumulation of nanoassemblies, overcome the biological barriers during intratumoral penentration of therapeutics, and achieve tumor-specific imaging and therapy. This progress report will summarize various types of recently reported smart DINAs for TME-responsive tumor imaging and therapy. Their future development towards potential clinical translation will also be discussed.

动态无机纳米组件 (DINAs) 已成为智能纳米医学平台，在生物成像和靶向药物输送方面具有广阔的潜力。在这篇综述中，我们及时了解肿瘤微环境 (TME) 响应性 DINA 的发展进展，以应对与精准癌症治疗相关的挑战。TME 响应性 DINA 旨在实现结构/功能的精确转换，以响应 TME 特异性刺激，包括活性氧 (ROS)、降低的 pH 值和缺氧，从而增强纳米组件的肿瘤积累，克服肿瘤内的生物屏障渗透疗法，实现肿瘤特异性成像和治疗。这份进展报告将总结最近报道的用于 TME 响应性肿瘤成像和治疗的各种类型的智能 DINA。