Mung Bean Protein Suppresses Undernutrition-Induced Growth Deficits and Cognitive Dysfunction in Rats via Gut Microbiota-TLR4/NF-kB Pathway,Journal of Agricultural and Food Chemistry

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Mung Bean Protein Suppresses Undernutrition-Induced Growth Deficits and Cognitive Dysfunction in Rats via Gut Microbiota-TLR4/NF-kB Pathway
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2021-10-15 , DOI: 10.1021/acs.jafc.1c05220
Zuchen Wei _{1,

2} , Yuanji Wang ₁ , Zhenxing Shi ₁ , Nong Zhou ₂ , Guixing Ren ₁ , Xiyu Hao ₃ , Liang Zou ₄ , Yang Yao ₁

Affiliation

Early undernutrition has been found to be closely associated with subsequent neurodevelopment. However, studies examining crude growth in terms of body weight/tail length cannot clarify how diets might mediate associations between the gut microbiota and cognitive dysfunction. In the present study, Sprague-Dawley (SD) rats were fed a 7% protein diet and mung bean protein diet (MBPD) for 6 weeks to assess central nervous system functions. Bifidobacterium longum subsp, Alloprevotella, and Lactobacillus were significantly altered after supplementary MBPD. Additionally, tryptophan, tyrosine, and glycine significantly restored in the brain, and the choline system also improved. Moreover, mung bean supplementation also upregulated expression of the brain-derived neurotrophic factor, postsynaptic density 95 protein (PSD95), synaptosome-associated protein 25 (SNAP25), downregulated toll-like receptor 4 (TLR4), and nuclear factor kB (NF-kB). Metabolites in the serum also underwent changes. Together, these results showed that malnutrition perturbed neurodevelopment, while MBPD reversed this trend.

中文翻译：

绿豆蛋白通过肠道微生物群-TLR4/NF-kB 通路抑制大鼠营养不良引起的生长缺陷和认知功能障碍

已发现早期营养不良与随后的神经发育密切相关。然而，根据体重/尾长检查粗增长的研究无法阐明饮食如何调节肠道微生物群与认知功能障碍之间的关联。在本研究中，Sprague-Dawley (SD) 大鼠喂食 7% 蛋白质饮食和绿豆蛋白质饮食 (MBPD) 6 周以评估中枢神经系统功能。长双歧杆菌亚种、别普氏菌属和乳杆菌属补充MBPD后显着改变。此外，大脑中的色氨酸、酪氨酸和甘氨酸显着恢复，胆碱系统也得到改善。此外，绿豆补充剂还上调了脑源性神经营养因子、突触后密度 95 蛋白 (PSD95)、突触体相关蛋白 25 (SNAP25)、下调的 Toll 样受体 4 (TLR4) 和核因子 kB (NF- KB）。血清中的代谢物也发生了变化。总之，这些结果表明营养不良会扰乱神经发育，而 MBPD 则扭转了这一趋势。

更新日期：2021-10-27

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